The Best Overall Multiviatamin Available

 Life Extension Mix™ Tablets without Copper

You hear it almost every day from government health agencies and privateorganizations. The unanimous directive is for Americans to eat more fruits and vegetables to live longer. Despite constant media publicity, the majority of Americans do not ingest enough fruits and vegetables each day. In fact, a Johns Hopkins study found that only 28% and 32% of American adults met the United States Department of Agriculture (USDA) guidelines for fruit and vegetable intake respectively.1 Yet, scientists are increasingly telling Americans that they must consume these kinds of plants in order to avoid a myriad of age-related problems.Life Extension Mix™ contains 94 unique vegetable, fruit, herbal extracts, amino acids, vitamins, and minerals. This state-of-the-art multi-nutrient formula has been updated numerous times since its launch in 1983. The Life Extension Mix™ formula is fortified with botanical extracts that help maintain healthy cellular functions. Consumption of these types of botanical extracts is being recommended based on research emanating from the world’s most prestigious medical centers. The latest Life Extension Mix™ formula now also contains a cutting-edge chromium complex to help maintain healthy glucose metabolism in those within normal range, a breakthrough antioxidant that helps support night vision, and a new lemon-based folate in an amount that makesyour personal dosing easier.

ANTIAGING BENEFITS OF PTEROSTILBENE

The formulation that already provides a broad spectrum of plant extracts now also contains trans-pterostilbene. This compound, found naturally in blueberries and grapes,has been shown to have beneficial anti-aging effects on gene expression and to promote healthy cognitive function. According to Dr. Agnes Rimando, a leading expert in the biology of stilbenes (resveratrol, pterostilbene and other related compounds), “Stilbenes have diverse pharmacological activities which include enhanced insulin sensitivity, and increased lifespan.”

PYRIDOXAL 5’-PHOSPHATE

When sugars react with your body’s proteins, the result is the formation of nonfunctioning

cross-linked structures called Advanced Glycation End Products (AGEs).3

While glycation is a normal consequence of aging, it is far from desirable.4-7 In fact,

similar glycation or “browning” reactions (called the Maillard reaction) occur in cooking

meat when proteins combine with the sugars present. This same “cooking” process

happens at a slower rate to your living body’s proteins!

The blurring of our eye lens with aging is a result of a lifetime of glycation reactions.8-10

Glycation is also associated with arterial blood flow problems and long-term kidney

issues.11-13 The pathological effect of glycation can also be seen outwardly in the form

of cross-linked proteins in senescent skin.14,15

Pyridoxal 5’-phosphate is the metabolically active B6 that has been shown to protect

against glycation reactions.16-19 The latest version of Life Extension Mix™ provides 100

mg of expensive pyridoxal 5’-phosphate in each daily dose.

STANDARDIZED POMEGRANATE EXTRACT

The pomegranate extract contained in Life Extension Mix™ is standardized to provide

the biologically active punicalagins that are so unique to this fruit. Pomegranate

punicalagins are 100% water-soluble and have shown a remarkable 95% absorption

rate.20 When tested against popular antioxidant food extracts, pomegranate

demonstrated one of the most potent free radical-suppressing effects. This means that pomegranate punicalagins not only absorb much better than other natural antioxidants, but they also have a superior antioxidant capacity. Peer-reviewed published human studies show that pomegranate helps maintain healthycardiovascular function by enhancing the endothelial nitric oxide synthase bioactivity, and inhibiting the oxidation of LDL cholesterol.21-24 Pomegranate also has the unique property of helping to maintain healthy DNA structure in the prostate cells.25-27 The daily dose of Life Extension Mix™ provides the equivalent of consuming up to 2.6 ounces of pomegranate juice —but without the sugar calories.

STANDARDIZED BLUEBERRY EXTRACTS

Blueberry anthocyanins are potent natural antioxidants that have demonstrated

properties that extend well beyond suppressing free radicals.

For instance, blueberries have been shown to not only improve memory but to also

undo some of the age-related changes seen in aging neurons. One study showed that

the ability of blueberries to suppress free radical damage in the brain was analogous to

long-term calorie restriction.28,29 These findings hint that blueberries might be able to

reverse certain aspects of brain aging!

Blueberry’s other active constituent (pterostilbene) promotes healthy lipid and glucose

levels for those already within normal range.30,31 Even more exciting is that these

blueberry constituents (pterostilbene and anthocyanins) may help protect DNA

structure.32

Life Extension Mix™ provides the standardized blueberry extracts that provide the

most active constituents found in this health-promoting fruit.

STANDARDIZED GREEN TEA EXTRACT

Life Extension introduced green tea extract as a supplement in 1993 based on

epidemiological studies showing that people who consumed green tea had lower

incidences of common age-related problems.33 Over the past 18 years, an enormous

volume of positive studies has been published about the health benefits of green tea.

Scientists have looked at the active “polyphenol” constituents of green tea and have

found that they possess remarkable biological activities that include inhibiting LDL

oxidation and neuronal peroxidation, while maintaining healthy DNA structure.34-40

Life Extension Mix™ contains 325 mg of a decaffeinated green tea extract that is

standardized to provide 98% of the active polyphenols that scientists attribute to green

tea’s multiple health benefits.

The amount of polyphenols, especially epigallocatechin-3-gallate (EGCG), in daily Life

Extension Mix™ is equivalent to drinking about one and a half cups of green tea per

day, and green tea powdered extracts have been shown to absorb 60% to 90% better

into the bloodstream compared with drinking green tea itself.41

STANDARDIZED VEGETABLE EXTRACTS

Luteolin is a flavonoid found in parsley, artichoke, basil, celery, and other foods.

When measured against 27 other flavonoids, luteolin provided one of the highest levels

of DNA protection.42

One favorable mechanism of luteolin is its ability to inhibit oxidative damage to cellular

DNA. Another unique benefit is luteolin’s ability to suppress excess levels of

dangerous inflammatory cytokines such as interleukin-6 and interleukin 1b.43,44

Life Extension Mix™ contains a standardized dose of 8 mg of luteolin, a dose that

emulates the benefits seen in published scientific studies.

Broccoli is touted as one of the most important vegetables to maintain healthy DNA

gene structure. Broccoli contains several active constituents, with sulforaphane being

the most significant because of its unique detoxification and DNA-protecting effects.

Life Extension Mix™ provides a concentrated broccoli mixture that provides

standardized extracts of sulforaphane and glucosinolates, two compounds attributed to

broccoli’s multiple protective benefits. Broccoli is also a natural source of geneprotecting

chlorophyll.45-52

D-glucarate is found in grapefruit, apples, oranges, broccoli, and brussels sprouts. dglucarate

effectively supports a detoxification process that helps to remove DNA toxins

from the body. The daily dose of Life Extension Mix™ provides 200 mg of

d-glucarate.53-55

Lutein, an extract found in corn and in leafy greens such as kale and spinach, has

been shown to help maintain critical pigments in the eye macula.56 The carotenoid

alpha carotene has demonstrated antioxidant activity greater than beta-carotene,

whereas lycopene from tomatoes has shown potent effects in helping to maintain DNA

structure and protecting against LDL oxidation.57-59 Life Extension Mix™ contains 60

times more lutein and 10 times more lycopene than popular one-per-day multivitamins.

Most multivitamin supplements provide no vegetable extracts whatsoever.

STANDARDIZED FRUIT EXTRACTS

In addition to standardized pomegranate and blueberry extracts, Life Extension Mix™

is also fortified with fruit extracts such as bilberry, grape seed, grape skin, and citrus

bioflavonoids to provide healthy circulation throughout the body and maintain healthy

DNA.

Scientists have long touted the multiple benefits of fruits such as blueberry, blackberry,

cranberry, plums, elderberry, persimmon, and cherry. Life Extension Mix™ provides a

customized blend of these and other fruits that studies indicate provide multiple

favorable effects in the body.

Olive oil consumption is one of the important factors behind the health benefits of the

“Mediterranean Diet.”60,61 Researchers have discovered that there are up to 300 times

more polyphenol compounds in olive juice compared to olive oil.62 Olive polyphenols

have been the subject of numerous in vitro, in vivo, and human studies pointing toward

their benefits in many different areas, including protecting against LDL oxidation,

suppressing free radicals, and stabilizing cell membranes.61-64 Life Extension Mix™

contains a potent olive extract standardized to provide the best-documented

polyphenol, hydroxytyrosol.65-67 The amount of hydroxytyrosol in the daily dose of Life

Extension Mix™ is equivalent to drinking more than one ounce of virgin olive oil a

day.68,69

SESAME LIGNANS ENHANCE THE EFFECTS OF VITAMIN E

Sesame and its lignans have a broad range of applications in human health. This

includes increasing human tissue levels of gamma-tocopherol by facilitating carrier

proteins in the liver to deliver nutrients to cells throughout the body.70,71

Sesame lignans increase the beneficial effects of fish oils and help maintain alreadynormal

cholesterol/LDL levels in humans.72-74 Life Extension Mix™ provides 10 mg of a

sesame lignan extract to supply the direct benefits of the lignans, and augment the

effects of vitamin E and other nutrients in the body such as gamma-linolenic acid

(GLA).

MAINTAINING HEALTHY BLOOD GLUCOSE LEVELS

Chromium, along with magnesium and biotin, is a nutrient required to maintain healthy

blood sugar for those already within normal range. Life Extension Mix™ provides 500

mcg of highly stable, biologically active chromium as Crominex® 3+ (a cutting-edge

chromium complex with Capros® Amla and PrimaVie® Shilajit), a better-absorbed

form of magnesium, and a super high-potency biotin. A review of studies showing

benefits of chromium supplementation reveals that doses exceeding 200 mcg a day

are required for optimal effects.75-81

HIGH-POTENCY VITAMIN D3

Doctors used to be concerned that too much vitaminD could be toxic. Over the past

few years, however, an increasing body of evidence indicates that it takes much higher

doses of vitamin D (perhaps over 10,000 IU/day) to inflict toxicity on a healthy person.

The concern expressed by researchers today is that fear of vitamin D toxicity is

keeping many people from supplementing with enough vitamin D, which is critical for

maintaining bone density and maintaining healthy cell division.82-86

As a matter of fact, a recent review in the New England Journal of Medicine suggested

recommended intakes for vitamin D are inadequate and need to be increased to at

least 800 IU of vitamin D3 per day.87 Currently, most experts in the field believe that

intakes of between 1,000 and 10,000 IU for adults will lead to a more healthy level of

serum 25(OH)D, at approximately 50–70 ng/mL.88,89

Life Extension recommends that healthy adults supplement each day with at least

2,000 IU of vitaminD. Many adults may benefit from higher doses of 5,000 to 10,000 IU

daily. (Those taking more than 4,000 IU a day should have their blood tested for 25-

hydroxyvitamin D in addition to blood tests for serum calcium and kidney function.)

In response to this latest research showing that even those who take standard vitamin

D supplements are not obtaining adequate amounts, Life Extension Mix™ now

provides 2,000 IU of vitamin D3 per daily dose. Another important consideration

regarding vitamin D utilization in the body is the amount of preformed vitamin A one

ingests. Most multivitamins contain too much preformed (not beta-carotene) vitamin A

that may interfere with the benefits of vitamin D. Life Extension multivitamins contain

only 500 IU of preformed vitamin A whereas commercial multivitamins often contain

5,000-25,000 IU of preformed vitamin A.90

NIGHT VISION SUPPORT WITH C3G

As we age, our ability to see in the dark is impaired. The reason is that a compound

called rhodopsin, that absorbs light in the retina, dramatically declines over time,

resulting in a progressive loss of dark vision.91

Researchers have discovered that a powerful antioxidant92 called C3G (cyanidin-3-

glucoside), found in blackberries and black currants,92,93 regenerates rhodopsin to

enhance night vision. In a study involving a group of healthy volunteers, just 50 mg of a

berry extract concentrate containing C3G helped aging individuals see better in

darkness after 30 minutes!94

Interestingly, bioavailable C3G also enhances other functions in the body as well.95-97

Its potent antioxidant properties protect tissues98,99 and support endothelial cell

health.100 Its beneficial effects on blood vessels are especially important in the retina,

where delicate nerve cells depend on the single ophthalmic artery for sustenance.

This newly enhanced Life Extension Mix™ formulation contains 1.25 mg of C3G to

support eye health.

THE MOST COMPLETE MULTI-NUTRIENT FORMULA

Life Extension Mix™ saves time and money by combining the most important nutrients

into one product, eliminating the need to take dozens of separate supplements

required to achieve the same effects.

Life Extension Mix™ supplies powerful antioxidant vitamins and plant extracts that

help protect against cellular DNA damage. Other ingredients in Life Extension Mix™

enhance beneficial DNA methylation patterns, help maintain glycemic control, and help

prevent the oxidation of LDL that contributes to the buildup of deposits in the

endothelial lining.

Life Extension Mix™ is the cornerstone of a comprehensive supplement program

because it provides so many well-studied nutrients. If you are on a budget, the Life

Extension Mix™ provides the bes“ct ost-per-milligram” v alue.

The Life Extension Foundation Buyers Club mandates that the ingredients in the Life

Extension Mix™ come only from premium -quality suppliers. These premium

companies charge more for their vitamins and trace elements, but the purity of these

substances greatly exceeds that of the lower cost generic versions that are so

prevalent in the vitamin industry.

Unlike most nutrients, it is difficult to determine the specific dose of copper each

individual should consume. The Life Extension Foundation Buyers Club recommends

no more than three-to-four mg of copper from all sources.

Who should not take copper: Some people appear to be especially sensitive to

copper supplementation. Those with Wilson’s disease should avoid copper

supplements altogether. Wilson’s disease is a genetic disorder that causes copper to

accumulate in the liver and then be abnormally delivered in large pools to different parts

of the body, where it inflicts damage. Also, cancer patients who are on a physiciansupervised

copper depletion therapy should avoid copper supplementation. As such,

Life Extension Foundation Buyers Club offers versions of Life Extension Mix™ without

any copper for those who are already obtaining enough copper from other sources or

those who should avoid supplements containing copper.

References

Supplement Facts

Serving Size 9 tablets (per day)

Servings Per Container 11

Amount Per Serving

Vitamin A (as 90% Betatene®1 D. salina natural betacarotene

with mixed carotenoids and 10% acetate)

5000 IU

Vitamin C (as calcium ascorbate, ascorbic acid, ascorbyl

palmitate, magnesium ascorbate, niacinamide ascorbate,

and acerola extract)

2000 mg

Vitamin D3 (as cholecalciferol) 2000 IU

Vitamin E (as D-alpha tocopheryl succinate) 400 IU

Thiamine (vitamin B1) (as thiamine HCI) 125 mg

Riboflavin (vitamin B2) (with 2 mg riboflavin 5’-phosphate

coenzyme)

50 mg

Niacin (vitamin B3) (as 53% niacinamide, 38% niacin, 9%

niacinamide ascorbate)

190 mg

Vitamin B6 (as 100 mg pyridoxal 5’-phosphate coenzyme

and 5 mg pyridoxine HCI)

105 mg

Folate [from (Citrus limon) extract (peel)] 400 mcg

Vitamin B12 (as 42% cyanocobalamin, 42%

hydroxylcobalamin, 16% ion exchange resin)

600 mcg

Biotin 3000 mcg

Pantothenic acid (as D-calcium pantothenate with 5 mg

pantethine)

600 mg

Calcium (as calcium ascorbate, D-calcium pantothenate,

Calcium D-Glucarate2)

218 mg

Iodine (as potassium iodide) 150 mcg

Magnesium (as magnesium oxide, citrate, glycinate

taurinate, arginate, ascorbate)

400 mg

Zinc (as OptiZinc®3 zinc monomethionine, zinc

succinate)

35 mg

Selenium [as 50% Se-Methyl L-Selenocysteine, 25% Lselenomethionine

(yeast free) (SelenoPure™4), and 25% 200 mcg

sodium selenate]

Manganese (as manganese gluconate) 1 mg

Chromium [as Crominex®5 3+ chromium stabilized with

(Capros® standardized Phyllanthus emblica extract (fruit)

and PrimaVie™ purified and standardized Shilajit)]

500 mcg

Molybdenum (as sodium molybdate) 125 mcg

Potassium (as potassium chloride) 37.4 mg

N-acetyl-L-cysteine (NAC) 600 mg

Taurine 200 mg

Inositol 250 mg

Phosphatidylcholine (from soy) 150 mg

Choline (as choline bitartrate) 120 mg

Boron (as boron citrate/aspartate/glycinate complex) 3 mg

Ascorbyl palmitate (fat-soluble vitamin C) 250 mg

para-Aminobenzoic acid (PABA) 200 mg

Trimethylglycine (TMG) (as betaine anhydrous) (from

sugar beets)

100 mg

Citrus bioflavonoid complex (Citrus aurantium L.) (peel

and fruit) [std. to 50% hesperidin (100mg)]

200 mg

Broccoli sprout concentrate (A proprietary blend of

broccoli sprout concentrates and Calcium D-Glucarate2)

(providing glucosinolates, sulforaphane, D-3T, and PEITC)

525 mg

Calcium D-Glucarate2 200 mg

Decaffeinated Green tea (Camellia sinensis) extract (leaf)

[standardized to 98% polyphenols (318.5 mg) and 45%

Epigallocatechin gallate (EGCG) (146.25 mg)]

325 mg

Acerola (Malpighia punicifolia) extract 4:1 (berry) 300 mg

Ginger (Zingiber officinale) extract (root) [standardized to

5% gingerols (10 mg)]

200 mg

HiActives 100% fruit/berry complex (A proprietary blend of

concentrated blackberry, blueberry, cherry, cranberry,

elderberry, persimmon, prune powders)

200 mg

Wild Blueberry (Vaccinium angustifolium) standardized

anthocyanin extract (fruit)

150 mg

Milk thistle (Silybum marianum) extract (seeds)

[standardized to 85% silymarin (85 mg)]

100 mg

POMELLA®10 Pomegranate (Punica granatum) extract

(fruit) [std. to 30% punicalagins (25.5 mg)]

85 mg

Bilberry (Vaccinium myrtillus) extract (fruit) [standardized

to 36% total anthocyaninins (10.8 mg)]

30 mg

Leucoselect®6 grape seed (Vitis vinifera) (seeds) extract

[std. to 95% proanthocyanidins (23.75 mg)]

25 mg

BioVin®7 grape (Vitis vinifera) extract (whole grapes) [std.

to 95% proanthocyanidins (23.75 mg)]

25 mg

Bromelain (from pineapple) (Ananas comosus) (stem)

(2400 gelatin digestive units per gram)

15 mg

Lutein (purified concentrate from marigold flowers)

(Tagetes erecta) (providing 465 mcg trans-zeaxanthin)

15 mg

Olive juice (Olea europea) extract (fresh fruit) [std. to 15%

polyphenols (1.875 mg)] (providing hydroxytyrosol, tyrosol

and oleuropein)

12.5 mg

Sesame seed (Sesamum indicum) lignan extract 10 mg

Luteolin (high purity luteolin, as Pureolin™8) 8 mg

Lycopene (from Lyc-O-Mato®9 natural tomato extract) 3 mg

Cyanidin-3-glucoside (C3G) 1.25 mg

trans-Pterostilbene (as pure Pterospan™11 and